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Staff/Senior/Principal Scientist – Protein Biology

Brisbane, CA

Nitrase Therapeutics, Inc., is a preclinical stage platform company developing disease modifying therapeutics against a novel class of enzymes to treat age related disorders: Oncological, neurological, cardiovascular, fibrotic. and inflammatory diseases.

We are seeking inquisitive individuals who can thrive in a collaborative and dynamic culture and are steadfast in the commitment to advance cutting-edge science to make transformative medicines for patients with unmet medical needs.


As part of Nitrase Therapeutics growth and drive toward the clinic, we are seeking to recruit a Staff/Senior/Principal Scientist, Protein Biology to our Brisbane, CA site with extensive hands-on experience in protein expression, purification and conjugation to support early discovery biology and drug discovery efforts.  The successful candidate will work with team members across scientific disciplines to apply functional proteomic and biochemical techniques to contribute to the understanding of nitrase activity in disease biology. Experience in experimental approaches such as protein expression and purification using various chromatographic strategies, biophysical analysis, protein conjugation/modification and functional characterization, and big data analysis tools are desirable.


  • Develop, execute, and analyze laboratory experiments in the areas of protein production and functional characterization
  • Oversee overall protein production of internal and external resources to provide both in vitro proof-of-concept and quantitative support for preclinical development of therapeutic compounds
  • Ability to quickly acquire knowledge, develop and troubleshoot protein expression studies to support therapeutic discovery programs.
  • Close collaboration with a cross-disciplinary teams and external groups to coordinate and drive complex studies
  • Clearly communicating results in written and oral formats
  • Maintaining notebooks and electronic files associated with each experiment
  • Preparing scientific presentations and manuscripts for publication
  • Developing and authoring SOPs and reports
  • Contribute to building a culture that encourages bold ideas, embraces scientific excellence, integrity, urgency and self-actualization


  • Degree (BA/BS, MS or Ph.D.) in Biology, Biochemistry or related scientific field
  • Minimum of MS + 7 years; Ph.D. + 5 years of protein expression, purification, modification and characterization experience.  Position title is commensurate with experience.
  • Experience with multiple protein expression systems
  • Experience with multiple liquid chromatogrpahy approaches for protein purification, biophysical and bioanalytical strategies
  • Expert knowledge of biochemical and molecular techniques
  • Proven ability to perform laboratory work and manage CROs
  • Industry drug discovery experience is a plus
  • Proven ability to work both independently and as an integrated player in a small team environment
  • Detail-oriented, proficient in oral and written communication
  • Ideal candidate will have a thorough ability to conduct high quality, creative bench level work while also understanding the big picture and how to move research forward efficiently
  • Compensation is competitive and commensurate with experience and qualifications

Nitrase Therapeutics is an equal opportunity employer

Salary Range: $150,000-$195,000 depending on experience

To apply, please send your resume and cover letter to, or by clicking below.