Nitrome purple tree

The Story Behind our Science

Nitrase Therapeutics was founded under the name Nitrome Biosciences by Irene Griswold-Prenner, Ph.D., our Chief Scientific Officer. By exploring the biological mechanism that led to the death of neurons in Parkinson’s disease, Irene was particularly intrigued by how oxidative stress might impact disease onset and progression and the role of nitration. At the time, it was widely thought that nitration was a chemically random process, like oxidation. Yet, based on her background and early research, she found a pattern of substrates nitrated in particular diseases. Specifically, the same proteins were nitrated in a variety of models of Parkinson’s disease. Through additional research, she determined that this type of specificity was actually an enzymatically-controlled reaction and implicated in disease manifestation. That discovery led to the identification of a protein with this enzymatic activity (a “nitrase”), and the company was born.

In 2021, under the leadership of the new Chief Executive Officer, Pierre Beaurang, Ph.D., the company changed its name to Nitrase Therapeutics to better reflect its unique discovery and therapeutic purpose with this new class of enzymes. The company’s approach is groundbreaking and highly differentiated, because we are the pioneers and discoverers of nitrases, we have unique insights into the mechanism of action and potential therapeutic applications of nitrases.